Endocrine Abstracts

Reversible Kallmann syndrome (KS) is a rare variant of hypogonadotropic hypogonadism (HH) reported in men, in which gonadotropin, testosterone (T) and fertility recover spontaneously following treatment with gonadotropins or T. In a few cases mutations of FGFR1 and KAL1 genes have been found. In this report we describe a subject with a KS carrying a new homozygous mutation of PROK-R2 gene and displaying an apparent reversal of his reproductive condition. The proband, born from...

The regulation of insulin-like factor 3 (INSL3) secretion from Leydig cells is still incompletely clarified. In this study we measured INSL3 serum levels in transsexual men under estrogen (E) and antiandrogen therapy or after orchiectomy. The effects of gonadotropins on testicular secretion in vitro was also evaluated.Methods: Blood samples were obtained from 14 transsexual men under long-term E (n=5) or E plus cyproterone acetate (E+CPA, <...